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Bio-X
Graduate Student Fellowships 2004
Sara Zhao
Mechanical Engineering
Professors Pruitt and Cho
Mechanotransduction, the process by which cells convert
mechanical stimuli into cellular signals, is important
in many areas of physiology, medicine, and medical device
design. The goal of this project is to study the MEC-4
channel complex that mediates sensory mechanotransduction
of touch receptor neurons. Working with Professor Goodman,
we will combine MEMS and biological techniques to characterize
the mechanosensitivity of the ion channel and its influence
on the cell structure and mechanical property. A bio
molecular model will be developed to describe the mechanism
of MEC 4 channel complex as mechanoreceptor and its
critical role in the whole-cell behavior. |
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