Dr. Chiu's laboratory aims to understand the mechanisms of pediatric solid tumors, precisely target the specific causes, and devise unique medical or surgical treatments for every child. This will be accomplished by pursuing the following goals: (1) Develop preclinical models that can faithfully recapitulate the tumor mechanism and microenvironment, (2) Design, create, and develop different controlled release platforms that can be loaded with novel therapeutics and applied in solid tumors, (3) Utilize molecular, genetic, immunological, bioengineering, and bioinformatics approaches to study mechanisms of tumor formation, progression, and metastasis, (4) Develop minimally invasive protocol capable of precisely targeting solid tumor and improving surgical resection margins