Awarded in 2017
Home Department: Bioengineering
Faculty Advisors: Stanley Lei Qi (Bioengineering, Chemical & Systems Biology) and Garry Nolan (Microbiology & Immunology)

Research Title: Dissecting the role of macrophage polarization in the tumor microenvironment

Research Description: Macrophages are an understudied and under-utilized cell type with great potential in the context of immunotherapy. These cells are a large component of the tumor microenvironment, where they can be “polarized” to express different functional programs in response to local molecular signals. Hannah will combine CRISPR-based tools and multiparametric single-cell immune analysis to study this polarization in the context of solid tumors. This work can help advance the informed development of future combination immunotherapies to force macrophages towards an anti-tumoral polarization state.

WHERE IS SHE NOW?

Hannah is a scientist at Aera Therapeutics.