Home Department: Biology
Supported by: Pitch and Catherine Johnson
Mentor: Joseph Wu, Medicine (Cardiovascular Medicine) and Radiology

Abhi aims to shed light on the molecular basis of familial hypertrophic cardiomyopathy by using TALEN-mediated gene editing to replace the mutant allele with the wild-type allele in patient-derived induced pluripotent stem cell (iPSC) lines. Cardiomyocytes derived from the mutant and 'corrected' iPSC lines will be analyzed using genome-wide expression profiling in order to build a molecular model of the genes and pathways associated with this disease.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 27, 2014:

Genetic Correction of Myosin-7 Mutations in an iPSC-Based Disease Model of Familial Hypertrophic Cardiomyopathy

Abhishek Venkataramana¹, Ioannis Karakikes², Vittavat Termglinchan², Sebastian Diecke², Joseph Wu²
[Departments of Biology¹ and Medicine (Division of Cardiology)², Stanford University]