Home Department: Human Biology
Supported by: Vice Provost for Undergraduate Education
Mentor: Frederick Chin, Radiology

Fragile X syndrome is a neurodevelopmental disorder caused by a mutation in the FMR1 gene. The disorder is characterized by abnormal body features and sensitivity to stimuli as well as intellectual, emotional, and behavioral disabilities. Through a competitive binding experiment and combined PET and MRI imaging on an established fragile X syndrome mouse model, Scarlett aims to develop a non-invasive imaging method potentially transferrable to human imaging to investigate the developmental physiology of the GABAergic neurotransmitter system at a critical stage of neurodevelopment and the onset of fragile X syndrome.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Multimodal Imaging of the FMR1 Knockout Mouse: A Model of Fragile X Syndrome

Scarlett Guo¹, Samantha Reyes¹, Bin Shen¹, Shawn Scatliffe¹, Jun Hyung Park¹, Zheng Miao¹, Jessa Castillo¹, Sanaz Mohajeri¹, Meng Gu¹, Christoph Leuze¹, Frederick T. Chin¹
[Department of Radiology¹, Stanford University]