Home Department: Biology
Supported by: Anonymous Donor
Mentor: Anne Brunet, Genetics

Frontotemporal Lobar Degeneration (FTLD) is a protein aggregation-associated neurodegenerative disease. The probability of developing FTLD increases with age. Sharon’s project focuses on examining the regulation of lysosomal transmembrane protein TMEM106B, a gene identified in a genome-wide association study to have protective effects against FTLD. Sharon will investigate the role of TMEM106B in proteostasis and healthy cognitive aging by studying TMEM106B in the brain of the newly pioneered model organism African Turquoise Killifish.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Aging-Induced Neurodegeneration in the African Turquoise Killifish

Sharon Chen¹, Andrew McKay¹, Anne Brunet²
[Departments of Biology¹ and Genetics², Stanford University]