Awarded in 2021
Home Department: Biophysics, Medicine
Faculty Advisors: Lacramioara Bintu (Bioengineering), Michael Bassik (Genetics), and Anshul Kundaje (Genetics and Computer Science)

Research Title: High-Throughput Characterization and Computational Modeling of Interactions Between Effector Domains in Chromatin-Mediated Gene Regulation

Research Description: Gene expression in humans is regulated in part by numerous chromatin regulators (CRs) that use effector domains to activate and repress transcription in a coordinated manner. Understanding how CRs work together to affect gene expression is critical to understanding gene regulation in human cells. In their studies, Adi will combine recruitment assays to measure transcription-regulatory function with high-throughput perturbation technologies and computational modeling. Adi will build a quantitative model of how different human protein domains combine to affect transcription; this will substantially deepen our understanding of chromatin biology and expand the range of tools we can use to build chromatin-based gene therapies.