Dr. Zachary Sellers is a pediatric physician-scientist striving to advance cystic fibrosis clinical care and translational research. Clinically, Dr. Sellers is focused on gastrointestinal manifestations of cystic fibrosis, developing diagnostic and therapeutic modalities to improve the gastrointestinal and liver health of those with cystic fibrosis. He also specializes in the clinical management of pediatric pancreatitis and am involved with the international INSPPIRE consortium to study pediatric pancreatitis.
Dr. Sellers's research spans the entire spectrum across basic science and translational research to clinical research and trials. In the laboratory, his projects are centered around understanding mechanisms of ion transport in cystic fibrosis tissues and determining how loss of CFTR ion transport leads to pathologic changes in human physiology. The Sellers lab is also very interested in the pathophysiological relationship between pancreatitis and intestinal diseases, such as inflammatory bowel disease. The laboratory has expertise in epithelial ion transport, with specialized skills in the measurement of bicarbonate transport. They are also part of a Multi-PI collaboration pursuing CFTR gene editing and stem cell engraftment for the treatment of cystic fibrosis. The Sellers lab utilizes a combination of immortalized and primary cell culture, organoids, mouse and human tissue, and whole animal in vivo studies.