Skip to content Skip to navigation

Predicting human drug-induced liver toxicity using chimeric mice

Sponsored Research Collaborations
Awarded in 2013


Gary Peltz (Anesthesia)
Jeffrey Glenn (Medicine)
Sara Michie (Pathology)

This project will determine if analyses performed in mice with humanized livers could better predict drug-induced liver toxicity in human subjects.

Project Description and Impact: Because of inter-species differences in drug metabolism and in their physiology, in vivo animal toxicology testing has not always accurately predicted whether drug-induced liver injury (DILI) will occur in humans. Because of this, un-expected DILI has become the most common reason for regulatory actions after drug approval. This application will determine whether a novel TK-NOG chimeric mouse with a highly humanized liver can more accurately predict whether DILI will occur in humans. This program will enable a 21st century experimental system to improve the safety of 21st century drug development.  These pioneering toxicology studies performed in humanized mice represent collaboration between a systems biologist who developed this advanced platform (G.P.), a hepatologist interested in HCV (J.G.), and an anatomic pathologist (SAM).