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Live-cell confocal microscopy for integration of engineered devices and neuroscience

NeuroVentures
Awarded in 2013

NeuroVentures Equipment Grant

Sarah Heilshorn, Materials Sci. & Engineering
Alex Dunn, Chemical Engineering
Jennifer Cochran, Bioengineering
Miriam Goodman, Molec. & Cell. Physiology
Calvin Kuo, Hematology
Theo Palmer, Neurosurgery
Giles Plant, Neurosurgery
Beth Pruitt, Mechanical Engineering
Sindy Tang, Mechanical Engineering

Collaborating faculty from departments in the School of Engineering and School of Medicine will receive funding for a confocal microscope for live cell imaging. Award recipients include Sarah Heilshorn (Materials Science), Andrew Olson (Neuroscience Microscopy Service, School of Medicine), Alex Dunn (Chemical Engineering), Jennifer Cochran (Bioengineering), Miriam Goodman (Molecular and Cellular Physiology), Calvin Kuo (Hematology), Theo Palmer (Neurosurgery), Giles Plant (Neurosurgery), Beth Pruitt, (Mechanical Engineering), and Sindy Tang (Mechanical Engineering). The new confocal microscope will be integrated with bioMEMS, microfluidic devices, nanoprobes, and novel materials, and will be used for high-resolution, time-lapse imaging of neural cell dynamics. The researchers will use the microscope to study a variety of neuroscience problems, including chemotaxis of neural cells, how cells develop in response to physical forces, dynamic cell responses to wounding, axonal regeneration, the development of nano-scale probes for brain tumor targeting and imaging, and engineering of peptides for the treatment of neurodegenerative diseases.