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Novel Silk Scaffolds for Pancreatic Islet Encapsulation

Seed Grants
Sponsored Research Collaborations
BioSTAR
Awarded in 20102011

BIO-X IIP SEED GRANTS PROJECT - 2010
SANOFI-SUPPORTED BIOSTAR SPONSORED RESEARCH PROJECT - 2011

Magali Fontaine (no longer at Stanford)
Annelise Barron (Bioengineering)
Sara Michie (Pathology)

Islet transplantation represents an improved treatment for patients with Type I Diabetes who have undergone destruction of their pancreatic beta-cells. This research project will focus on using bioengineering and stem cell technology to develop a novel biocompatible scaffold that will aid in survival and function of transplanted islets. The scaffold will be fabricated from FDA approved silk and surrounded by nanoporous collagen sheets to minimize immune-mediated destruction by the graft recipient. Furthermore, stem cells will be co-encapsulated and transplanted with the islets to enhance graft survival and function, and provide immune protection. In the spirit of BioX-supported interdisciplinary research, this project combines the Fontaine lab’s expertise in islet cell isolation and transplantation, the Barron lab’s expertise in biomaterial science with the Michie’s lab’s insight into regulation of inflammatory cell trafficking and holds enormous medical potential for developing a new platform of beta cell replacement therapy.

In the spirit of Bio-X-supported interdisciplinary research, this project combines the Fontaine lab’s expertise in islet cell isolation and transplantation, the Barron lab’s expertise in biomaterial science with the Michie’s lab’s insight into regulation of inflammatory cell trafficking and holds enormous medical potential for developing a new platform of beta cell replacement therapy.