This project aims to develop safe, colorless methods to temporarily or permanently improve the transparency of tissues in and around the eye to enhance medical imaging and help restore vision. Clear vision depends on precise light transmission, yet some eye tissues are naturally opaque (such as the sclera, the white outer coat), which limits a clinician’s ability to directly view deeper structures, while other tissues (such as the cornea) can become cloudy after injury or disease, sometimes leaving transplantation as the only option. Building on emerging scientific principles showing that light scattering can be reduced by adjusting how strongly tissue fluids bend light, we will explore biocompatible, naturally inspired molecules designed to reduce scattering without relying on visible dyes. The work will evaluate whether these materials can (1) create a reversible “optical window” through normally opaque outer eye tissue to improve visualization of deeper anatomy and (2) improve clarity in scarred corneas and extend that benefit by using clinically compatible stabilization strategies. Using established laboratory and preclinical evaluation methods, we will measure improvements in transparency and imaging performance while carefully assessing ocular tolerance and tissue health. Success would establish a broadly applicable approach for on-demand control of ocular transparency, with potential future impact on eye imaging, surgical guidance, and new options for restoring corneal clarity.