Kidney stone disease affects about 1 in 9 people, costing > $4 billion in healthcare expenditures per year in the United States. Stones can cause tremendous pain and often will require surgery.  However, their most common surgical treatment (ureteroscopic laser lithotripsy) is limited by incomplete stone removal which can lead to the persistence of symptoms and recurrence of stones. Depending on the size, stone fragment removal can be inefficient, tedious, and highly resource intensive in the operating room. Rendering a patient stone-free is the best way to prevent further complications or repeat interventions due to residual stone fragments yet reported stone-free rates only approach 60-75%. There is a strong unmet need for a more efficient strategy to improve the stone-free rate to enhance treatment effectiveness, reduce patient morbidity, and streamline healthcare resource utilization. The objective of this application is to develop a new approach based on spinning induced suction mechanism to vastly improve the efficiency of stone fragments retrieval, and to set the stage for clinical tests in humans. Our hypothesis is that by using a rationally designed spinner, the suction induced by the spinning spinner is strong enough to draw and capture stone fragments. This approach is novel in the sense of aiming at passively bringing stones/fragments to the device rather than actively chasing them as it is currently done with the standard of care nitinol baskets and aspiration/suction devices. We propose to study the fluid dynamics of varied spinner designs for device optimization to effectively capture human-derived fragments of any size and chemical compositions. In addition, we want to explore the preliminary safety in ex vivo porcine kidneys and the proof-of-concept and head-to-head comparison in a realistic ureteroscopy simulator. The results of this novel work will position us for future grant support. The proposed research is significant because it has the potential to substantially improve clinical outcomes and reduce healthcare costs related to kidney stone surgery.