Frontiers in Quantitative Biology Seminar

LAURA JOHNSTON, COLUMBIA UNIVERSITY

Dr. Johnston's laboratory investigates the mechanisms used by growing tissues to gauge and regulate the collective and individual fitness of cells, thereby optimizing tissue and animal fitness. They are interested in the basic biological mechanisms that regulate these processes, how they contribute to development of healthy tissues and in understanding their relevance to developmental and tumorigenic pathologies. They use the simple genetic model organism Drosophila and utilize strategies that allow manipulation of growth and cell fitness in living, growing animals. Their projects include: how the growth regulator Myc mediates competitive interactions during tissue and organ growth; investigation of homeostatic processes, including metabolism, that allow cells to sense and respond to growth changes in their local environment; identification of factors that act as sensors and mediators of cellular fitness; and genetic and molecular dissection of tissue regeneration. These processes provide plasticity to growing organs and give cells control over their local environment.

February 23rd, 2017 at 2:15 PM in Clark Center Seminar Room S360

Frontiers in Quantitative Biology 2016/2017 Seminar Series

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