Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main targets of the humoral immune response. We demonstrated that ACE2 is a functional entry receptor for this novel coronavirus and that the receptorbinding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to ACE2, which correlates with the efficient spread of SARS-CoV-2 among humans.
The Extavour Lab is a collection of developmental biologists, molecular biologists, geneticists, cell biologists, zoologists, and evolutionary biologists. Their shared interest is in the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development and differentiation. They focus primarily on the evolution and development of reproductive systems, including both the germ line and the somatic components of the gonad.
This and other Stanford Bio-X seminars and events will be conducted virtually over Zoom. Please join the meeting with the information LIsted and mute your computer's audio if needed. You will need to be signed in to a Zoom account to join.
The Bonini lab specializes in using the genetically tractable model organism, Drosophila, as a tool to understand the molecular basis of disease and disorder of the brain, with a particular focus on degenerative processes including ALS/FTD, TBI and aging. They implement cutting-edge genetic, molecular and cellular approaches to develop and characterize models of these processes to study their molecular basis, with an emphasis on potential translatability to clinical improvement.
This and other Stanford Bio-X seminars and events will be conducted virtually over Zoom. Please join the meeting with the information on the webpage and mute your computer's audio if needed.
The Rabinowitz Lab aims to achieve a quantitative, comprehensive understanding of cellular metabolism. Their motivation for studying metabolism is two-fold. From a basic science perspective, the molecular connections involved in metabolism are the best understood of any major biochemical network. Accordingly, metabolism provides a unique opportunity for quantitative analysis. From a practical perspective, derangements of metabolism are a major cause of disease, and small molecules that inhibit metabolism are the basis of many important pharmaceuticals. Accordingly, systems-level analysis of metabolism is likely to yield discoveries of medical significance.
The Klein Lab studies how cells make decisions during embryo development and tissue regeneration. They utilize the lung, the blood, and early vertebrate embryos as our model systems. To gain a quantitative understanding of cellular decisions, they develop experimental and statistical approaches to measure cellular and tissue phenotypes. They additionally use theoretical approaches to infer principles from quantitative phenotypes.
The Wang lab applies synthetic and systems biology approaches to design and build new microbes with novel capabilities, leveraging both engineering and evolutionary principles. They are interested in developing platform technologies and using them to answer fundamental biological questions. Their research interests include: genome engineering; human microbiome; synthetic ecosystems; evolution and epistasis; and new genetic codes.
The neuronal heterogeneity and complex connections of the brain reward system prevented a deeper understanding of the drug addiction mechanisms. The study Dr. Zhang will present provides a broadly applicable strategy for understanding the molecular, cellular and circuitry mechanism of drug addiction and other psychiatric diseases.