Christine Stabell Benn has found in population-based epidemiological studies in one of the world’s poorest countries, Guinea-Bissau, that vaccines not only protect against the target infection, they also affect the susceptibility to other infections.
Dr. Brooks's laboratory focuses on the study of somatic mutations that cause changes to the transcriptome, particularly through mRNA splicing. They aim to gain a better understanding of how alternative splicing is regulated and the functional consequences of splicing dysregulation through the study of these cancer genome alterations.
Dr. Doe and his lab group study the assembly of the nervous system in the fruit fly Drosophila. They are interested in how neuronal diversity is generated, how it is used to establish neuronal circuits, and how circuits generate diverse locomotor behaviors.
Dr. Harley's group develops biomaterials that replicate the dynamic, spatially-patterned, and heterogeneous microenvironment found in the tissues and organs of our body. They use this approach to generate new insight regarding how biomaterial cues can instruct cell responses in the context of development, disease, and regeneration. In this talk, Dr. Harley will describe a collagen biomaterial under development to address barriers preventing regeneration of musculoskeletal tissues such as orthopedic insertions and craniomaxillofacial bones.
The Zimmer lab focuses on complex carbohydrates and how they are synthesized and deposited on the cell surface. Using the tools of structural and molecular biology, they study capsule and biofilm formation in bacteria, cell wall biosynthesis in plants, and extracellular matrix formation in vertebrates.
Work in the Green lab is centered on the ribosome, and can be roughly divided into four general project areas. The longest-standing research area concerns the interactions of eubacterial ribosomes and release factors. The goal of these projects is to understand the mechanism of action of release factors on the ribosome.
The François lab is interested in the theoretical aspects of evolution, real and simulated. They have developed tools to evolve models of "gene networks" in silico, performing predefined biological functions. They have applied and predicted structure of networks for systems ranging from genetic oscillators, biochemical adaptation to development and immune system.
The Horne-Badovinac lab uses genetic, cell biological and quantitative live imaging approaches to investigate how organs take on their unique shapes during development. Currently, they seek to understand how collective cell migration and basement membrane remodeling shape the fly egg.
The Di Talia laboratory develops live imaging and computational methods to probe the dynamics of the signaling pathways that control cell division during development and regeneration. They aim to uncover the dynamical principles that ensure that embryonic development and regeneration are regulated in a reliable manner.
Adam Deutschbauer has a background in Microbial systems biology. As part of the Virtual Institute of Microbial Stress and Survival, he develops next-generation tools for microbial functional genomics. As the Biotechnology Component Deputy Director, he helps drive the development of experimental and computational approaches to develop models of microbial metabolism, gene regulation, and signal transduction.
How developing organisms generate and maintain cells with specialized functions and fates is a fundamental problem in biology. The Cabernard lab is investigating asymmetric cell division (ACD), a process that generates cellular diversity. They are using Drosophila melanogaster neuroblasts, the neural stem cells in the fly as a model to study the molecular cell biology and mechanics of asymmetric stem cell division.
The Gladfelter lab is interested in how cells are organized in time and space. They study how cytoplasm is spatially patterned and how cells sense their own shape. They also investigate how timing in the cell division cycle can be highly variable yet still accurate. For their work, we combine quantitative live cell microscopy and computational, genetic and biochemical approaches in fungal and mammalian cells.