In this lecture, we will present our recent work in the field of cryo-ET and in situ structural biology, highlighting technological developments and their potential, and offering a perspective to obtain "anatomical" details at the molecular level from larger cells or tissues - towards a biopsy at the nanoscale.
Dr. Doe and his lab group study the assembly of the nervous system in the fruit fly Drosophila. They are interested in how neuronal diversity is generated, how it is used to establish neuronal circuits, and how circuits generate diverse locomotor behaviors.
Christine Stabell Benn has found in population-based epidemiological studies in one of the world’s poorest countries, Guinea-Bissau, that vaccines not only protect against the target infection, they also affect the susceptibility to other infections.
Dr. Brooks's laboratory focuses on the study of somatic mutations that cause changes to the transcriptome, particularly through mRNA splicing. They aim to gain a better understanding of how alternative splicing is regulated and the functional consequences of splicing dysregulation through the study of these cancer genome alterations.
Dr. Harley's group develops biomaterials that replicate the dynamic, spatially-patterned, and heterogeneous microenvironment found in the tissues and organs of our body. They use this approach to generate new insight regarding how biomaterial cues can instruct cell responses in the context of development, disease, and regeneration. In this talk, Dr. Harley will describe a collagen biomaterial under development to address barriers preventing regeneration of musculoskeletal tissues such as orthopedic insertions and craniomaxillofacial bones.