Frontiers in Quantitative Biology Seminar
LUCAS PELKMANS, UNIVERSITY OF ZURICH
The Pelkmans lab operates at the forefront of research in quantitative cell biology, in the study of cell-to-cell variability, as well as in systems approaches based on large- scale genetic perturbations and network biology. Over the years, they have made groundbreaking discoveries in virus entry, endocytosis, and the assembly of caveolae. They pioneered multi-parametric image-based RNAi screens in mammalian cells, they were the first to reveal that cell-to-cell variability in human cells is largely predictable, they have defined a novel type of regulatory genetic interaction and mapped these in the endocytic membrane system, and they invented image-based transcriptomics. They have also uncovered a novel principle by which a kinase couples liquid phase transitions in the cytoplasm to signal transduction, and identified a cell-intrinsic molecular mechanism by which cells adapt their lipid composition to local crowding, driving variability in single- cell behavior and pattern formation in cell populations. The lab is highly motivated to stay at the forefront of these fields by developing new computational and single- cell methods and by combining unbiased data-driven research with reductionist approaches in innovative ways.
March 9th, 2017 at 2:15 PM in Clark Center Seminar Room S360
Frontiers in Quantitative Biology 2016/2017 Seminar Series
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