The Ünal lab studies the principles that control the nuclear and cytoplasmic integrity of gametes. They are interested in understanding the principles and regulation of meiotic differentiation. This process, also known as gametogenesis, is a dynamic and tightly regulated developmental program. Upon commitment, a progenitor cell undergoes DNA replication and recombination followed by two consecutive meiotic divisions and cellular remodeling to form haploid gametes; the mature germ cells necessary for the propagation of sexually reproducing organisms. A fundamental question is how the fitness of gametes is ensured during their production such that they contain the appropriate nuclear and cytoplasmic content to make healthy progeny.
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