Move Over, Mice: How Integration of Systems Biology with Organs-on-Chips May Humanize Therapeutic Development

LINDA GRIFFITH, MIT

“Mice are not little people” – a refrain becoming louder as the strengths and weaknesses of animal models of human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks in patient-derived samples; 3D tissue engineered models of human organ systems, often made from stem cells; and micro-fluidic and meso-fluidic devices that enable living systems to be sustained, perturbed and analyzed for weeks in culture. This talk will highlight the integration of these rapidly moving fields to understand difficult clinical problems, with an emphasis on translating academic discoveries into practical, widespread use. These technologies may have broad impact on regenerative medicine, as they may foster development of therapies that slow or halt progression of diseases that lead to organ or tissue failure.

April 28th, 2016 at 12:15 PM in Clark Center Seminar Room S360

Hosted by:

Ovijit Chaudhuri, Assistant Professor of Mechanical Engineering

Pre-Seminar April 26th, 2016 at 12:15 PM in Clark S361