The Campbell Muscle Lab at the University of Kentucky seeks sarcomere level therapies for human heart failure. The lab’s research integrates biophysical, biochemical, and computational techniques and is performed in close collaboration with cardiothoracic surgeons and cardiologists. In this seminar, Ken Campbell will present data showing that healthy human hearts exhibit transmural variation in contractile function (power output, force development, and calcium sensitivity) and that heart failure disrupts the normal transmural patterns. He will also show new data demonstrating that cardiac relaxation is modulated by the myocardial strain rate at end systole. This result suggests that it may be possible to improve diastolic dysfunction by targeting myofilament kinetics and/or by modifying tissue strain rates.
Small lunch will be served at 12:00 PM.
Beth Pruitt, Associate Professor of Mechanical Engineering, Stanford University
Pre-Seminar September 29th, 2014 at 12:15 PM in Clark S361