Sarcomere level function in human heart failure

KEN CAMPBELL, UNIVERSITY OF KENTUCKY

The Campbell Muscle Lab at the University of Kentucky seeks sarcomere level therapies for human heart failure. The lab’s research integrates biophysical, biochemical, and computational techniques and is performed in close collaboration with cardiothoracic surgeons and cardiologists. In this seminar, Ken Campbell will present data showing that healthy human hearts exhibit transmural variation in contractile function (power output, force development, and calcium sensitivity) and that heart failure disrupts the normal transmural patterns. He will also show new data demonstrating that cardiac relaxation is modulated by the myocardial strain rate at end systole. This result suggests that it may be possible to improve diastolic dysfunction by targeting myofilament kinetics and/or by modifying tissue strain rates.

October 2nd, 2014 at 12:15 PM in Clark Center Seminar Room S360

Small lunch will be served at 12:00 PM.

Hosted by:

Beth Pruitt, Associate Professor of Mechanical Engineering, Stanford University

Pre-Seminar September 29th, 2014 at 12:15 PM in Clark S361