Dr. Kenneth Yamada's group's overall research goals are to discover novel mechanisms and regulators of cell interactions with the extracellular matrix and their roles in craniofacial development and disease pathogenesis. They are focusing on mechanisms by which the extracellular matrix, integrins, Rho family GTPase signaling systems, and the cytoskeleton act in concert to mediate or regulate cell adhesion, migration, invasion, matrix remodeling, and tissue morphogenesis.
Recent microscopy and cell biology approaches are revealing new mechanisms underlying cell migration and mammalian embryonic organ formation. We can now visualize and semi-quantify the highly dynamic, two-way interactions of human cells with the 3D extracellular matrix in vitro to compare migration of normal and cancer cells. The mechanobiology underlying cell migration, spatially regulated deposition of matrix, and sculpting of initially unorganized cells into complex branched organs are being characterized and experimentally manipulated using mouse embryonic organ culture and 3D human cell and spheroid models. These studies provide unexpected new insights into the dynamic forces and specific molecules involved in 3D cell migration and the remodeling of epithelial cells into 3D embryonic tissue architecture.
Ovijit Chaudhuri, Assistant Professor of Mechanical Engineering, Stanford University
Pre-Seminar February 18th, 2020 at 4:00 PM in Clark S361