Stanford Bio-X Seminar: David Veesler - "Structural studies of coronavirus fusion glycoproteins"
Stanford Bio-X Seminar
David Veesler, Assistant Professor of Biochemistry, University of Washington
Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main targets of the humoral immune response. We demonstrated that ACE2 is a functional entry receptor for this novel coronavirus and that the receptorbinding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to ACE2, which correlates with the efficient spread of SARS-CoV-2 among humans.