Dr. Maecker's laboratory research focuses on cellular immune responses to pathogens and cancer, and the correlation of those responses with protection from clinical disease. They use systems-level immune monitoring assays, and currently have projects focused on cytomegalovirus (CMV), EBV, HIV, and cancer. These are all settings where cellular immunity is important, and thus they wish to map the detailed phenotypes and functions of the immune cells involved. Correlating these phenotypes and functions with disease outcome or therapeutic responsiveness would enable better vaccine development and monitoring of individuals undergoing immunotherapy.