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459 Course

Previous speakers have come from universities and corporations all over North America.  

Click below to jump to a series year:

2014/2015 2013/2014 2012/2013 2011/2012 2010/2011
2009/2010 2008/2009 2007/2008 2006/2007 2005/2006
2004/2005 2003/2004 2002/2003 2001/2002 2000/2001
1999/2000 Upcoming

2014/2015 Series:

2 October, 2014
Ken Campbell, University of Kentucky
“Sarcomere Level Function in Human Heart Failure”

23 October, 2014
Bing Ren, UCSD School of Medicine
“Regulation of the 3D Genome”

20 November, 2014
Lior Pachter, UC Berkeley
“Recent Developments in RNA-Seq”

15 January, 2015
David Mangelsdorf, University of Texas Southwestern
“Catching Fire: Surviving the Hunger Games through Nuclear Receptor/FGF Signaling”

26 February, 2015
Jeffrey Hubbell, University of Chicago
“Materials and Protein Engineering for Engineering Immunity and Tolerance”

12 March, 2015
Fred Rieke, University of Washington
“Parallel Processing and Computation in Neural Circuits”

9 April, 2015
Julia Kaltschmidt, Memorial Sloan Kettering Cancer Center in NYC
“Molecular Specialization in the Assembly of Presynaptic Inhibitory Synapses”

7 May, 2015
Rob Tycko, NIH NIDDK
“Molecular Structural Basis for Amyloid Formation in Alzheimer’s Disease”

4 June, 2015
Olga Boudker, Cornell University School of Medicine
“Membrane Transporters Beyond Crystal Structures: Dynamics and Thermodynamics of Glutamate Transporters”

2013/2014 Series:

10 October, 2013
Shirley Villadiego, OrthoClinical Diagnostics, Johnson and Johnson
“From ideation to implementation: The journey of creating solutions that work in global health”

31 October, 2013
Peter Pinsky, Stanford University
“Computational modeling of the human cornea: transparency, metabolism, strength and shape”

21 November, 2013
Xinzhong Dong, Johns Hopkins University
“Itch mechanisms”

16 January, 2014
Kristi Anseth, University of Colorado in Boulder
“Dynamically tunable hydrogel matrices: Cell biology in the fourth dimension”

13 February, 2014
Kun Zhang, University of California San Diego
“Single-cell analysis of the brain”

13 March, 2014
Gordon Fishell, New York University
“Cortical Interneurons: creation, wiring and disease”

10 April, 2014
Jason Sello, Brown University
“Microbially inspired solutions to challenges in medicine and in alternative energy”

1 May, 2014
Thea Tlsty, University of California San Francisco
“Rare somatic cells from human breast tissue exhibit extensive lineage plasticity”

22 May, 2014
Geeta Narlikar, University of California San Francisco
“Molecular mechanisms of chromatin remodeling motors”

2013/2012 Series:

4 October, 2012
Sebastian Seung, MIT
“Relating activity and connectivity in neural networks”

25 October, 2012
Jay Groves, University of California, Berkeley
“Spatial organization and the mechanics of signal transduction at the single molecule level”

29 November, 2012
Philipp Keller, Janelia Farm Research Campus, Howard Hughes Medical Institute
“Reconstructing neural development”

17 January, 2013
Eero Simoncelli, New York University
“Probing sensory representations with metameric stimuli”

14 February, 2013
Ratmir Derda, University of Alberta
“Discovery of ligands from genetically-encoded libraries of synthetic molecules”

7 March, 2013
Jill Mesirov, Broad Institute
“Computational Approaches to Genomic Medicine”

11 April, 2013
Douglas DeSimone, The University of Virginia
“Mechanical Force and the Regulation of Morphogenesis”

9 May, 2013
David Haussler, UC Santa Cruz
“Big data and new models needed to study DNA variation in evolution and cancer”

6 June, 2013
Lloyd Minor, Stanford University
“Navigating the Labyrinth of the Inner Ear: Achieving 'Balance' as a Clinician Scientist”

2011/2012 Series:

27 October, 2011
Rafael Irizarry, John Hopkins University
“Epigenetic variation as a driving force for development and cancer”

17 November, 2011
Barak Cohen, Washington University in St. Louis
“Thermodynamic models of cis-regulation”

8 December, 2011
Kevin Haigis, Harvard University
“In vivo systems biology of inflammatory signaling in the GI tract”

26 January, 2012
Mehmet Toner, Surgery, Harvard
“Bioengineering and Clinical Applications of Circulating Tumor Cell (CTC) Chip”

16 February, 2012
Hang Lu, Georgia Institute of Technology
“Microtechnologies for High-throughput High-content Developmental Biology and Neurogenetics”

15 March, 2012
Thomas Steitz, Yale University
“From the Structure and Function of the Ribosome to New Antibiotics”

12 April, 2012
Jacob Schaefer, Washington University, St. Louis, MO
“Carbon partitioning, metabolism, and cell-wall structure in leaves under elevated CO2 conditions using in vivo 11C and 13C labeling”

10 May, 2012
Jonathan Stamler, Case Western Reserve University
“Protein S-nitrosylation and potential for therapeutic allostery”

7 June, 2012
Steven Henikoff, Fred Hutchinson Cancer Research Center
“Mapping genome-wide nucleosome dynamics”

2010/2011 Series:

30 September, 2010
Frank Bova, University of Florida
“20 years of Radiosurgery and Image Guided Surgery”

11 November, 2010
Douglas Lauffenburger, MIT
“Thermodynamic models of cis-regulation”

18 November, 2010
Daniel Beard, Medical College of Wisconsin
Systems Analysis of Metabolic Function in the Heart—from Molecules to Cells to Whole-Organ Function

13 January, 2011
Dan Roden, Surgery, Vanderbilt University
Personalizing Medicine the Vanderbilt way

17 February, 2011
Fred Chang, Columbia University
How cells divide in the middle

10 March, 2011
Gregory Petsko, Brandeis University
Specific Inhibition of Nucleation of Alpha-Synuclein Aggregation As a Therapeutic Strategy for Parkinson's Disease

7 April, 2011
David Botstein, Princeton University
“Coordination of Growth Rate, Cell Cycle, Stress Response and Metabolic Activity in Yeast”

28 April, 2011
David Weitz, Harvard University
Fluctuations and dynamic arrest in cells

26 May, 2011
Peter Wolynes, University of California, San Diego
“Recent Successes of the Energy Landscape Theory of Protein Folding”

2009/2010 Series:

1 October, 2009
Denis Wirtz, John Hopkins University
The biophysical basis of laminopathies

29 October, 2009
Nicole King, University of California, Berkeley
Choanoflagellate morphogenesis, interspecies signaling and the origin of animal multicellularity

3 December, 2009
David Jaffray, University Toronto
Advancing the Image-guidance Radiotherapy Paradigm: Investigations in Nanotechnology

14 January, 2010
Anthony Leonardo, Janelia Farm Research Campus of the HHMI
Neuronal and behavioral dynamics underlying prey capture in the dragonfly

11 February, 2010
Bob Langer, MIT
Biomaterials and biotechnology:  From the discovery of angiogenesis inhibitors to the development of drug delivery systems and the foundation of tissue engineering

4 March, 2010
Eric Siggia, Rockefeller University
Predicting the course of evolution

15 April, 2010
Peter Tyack, Woods Hole Oceanographic Institute
Using electronic tags to discover how toothed whales echolocate to find and capture prey in the deep ocean

6 May, 2010
Joseph Wang, UCSD
Can Man-Made Nanomachines Compete with Biomotors?"

27 May, 2010
Joanna Aizenberg, Harvard University
Bio-inspired, reconfigurable, “spiny” surfaces: En route for adaptive materials

2008/2009 Series:

2 October, 2008
Matthew Rabinowitz, Stanford University
“An Informatics Technology using Arrays for Reliable Single-Cell Genetic Diagnosis”

30 October, 2008
Robert Seyfarth and Dorothy Cheney, University of Pennsylvania
“Baboon metaphysics: The evolution of a social mind”

20 November, 2008
Frans De Waal, Emory University
“On the Possibility of Animal Empathy”

15 January 2009
Jonathan Weissman, UCSF
"Genome-wide in vivo analysis of translation with sub-codon resolution by ribosome profiling"

26 February, 2009
Terence Hwa, UCSD
“On growth, antibiotics, and evolution”

12 March, 2009
Judith Frydman, Stanford University
“Molecular Origami: the complex art of protein folding in the cell”

9 April, 2009
Ellen Kuhl, Stanford University
“The Virtual Heart: A Multiscale Continuum Approach towards Computational Cardiology”

14 May, 2009
Susan Mango, The University of Utah
 “Molecular basis of organ formation”

4 June, 2009
Josh Sanes, Harvard University
“Synaptic circuitry in the visual system”

2007/2008 Series:

November 1, 2007
Jennifer J. Kohler, UT Southwestern Medical Center
“Glycosylation in the Golgi: Understanding and Exploiting a Biosynthetic Machine”

November 15, 2007
Taher Saif, University of Illinois at Urbana-Champaign
“Cellular Mechano-Sensitivity – A New Paradigm in the Understanding of Learning and Memory”

November 29, 2007
Annelise Baron, Stanford University
“A Biomimetic Lung Surfactant with Peptoid Analogs of the Hydrophobic Surfactant Proteins”

January 24, 2008
Alice Ting, Massachusetts Institute of Technology
“Chemical Reporters for Live Cell Imaging”

February 14, 2008
Tzung Hsiai, University of Southern California
“Shear Stress and Oxidative Stress: Implication for MEMS sensors”

March 13, 2008
Bruce Rosen, Harvard University
“Frontiers in Multimodal Brain Imaging”

April 10, 2008
Benoit Roux, The University of Chicago
“Free Energy Landscape and the Function of Biomolecules”

May 1, 2008
Farshid Guilak, Duke University
“Functional Tissue Engineering of Cartilage”

May 22,
Brenda Schulman, St. Jude Children's Research Hospital
“Osteoarthritis and Fat: The Good, The Bad, and The Ugly”

2006/2007 Series:

12 October, 2006
Andrew Link, Vanderbilt University                  
“Systematic Proteomic Analysis of Eukaryotic Translation Complexes”

2 November, 2006
Channing Robertson, Stanford University       
“Bio-X/Clark Center: The Beginnings”

16 November, 2006
James Swartz, Stanford University                  
“Engineering Biology without Cells: Science and Applications”

11 January, 2007
Kevan Shokat, UCSF                                      
“Chemical Genetic Analysis of Normal and Disease Physiology”

1 February, 2007
Sebastian Bonhoeffer, ETH                            
“Recombination and Drug Resistance in HIV-1: An Evolutionary Perspective”

15 February, 2007
Tillman Gerngross, Dartmouth College
“Engineering the Yeast Secretory Pathway for the Production of Human Glycoproteins”

12 April, 2007
Erich Jarvis, Duke University                          
“Insights from Birdsong into the Neurobiology of Language”

3 May, 2007
Xiaowei Zhuang, Harvard University               
“Single-Molecule and Super-Resolution Optical Imaging of Biomolecules and Cells”

17 May, 2007
Danesh Moazed, Harvard University               
“Chromosome-Associated RNAi and its Role in Heterochromatin Assembly and Function”

2005/2006 Series:

13 October, 2005
Chris Chen, University of Pennsylvania          
“Forces, Form and Stem Cell Function:  Mechanotransduction at the Cellular and Multicellular Scale”

3 November, 2005
James Miller, Washington University in St. Louis                    
“Nonlinear Ultrasonic Imaging: A Tool for Probing Normal and Diseased Hearts”

1 December, 2005
Giulio Tononi, University of Wisconsin
“Sleep and Synaptic Homeostasis: New Ideas about Sleep Function”

26 January, 2006
Mario Capecchi, University of Utah                
“Gene Targeting into the 21st Century:  Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders”

9 February, 2006
Marius Clore, NIH                  
“Insights into Recognition in Transient Macromolecular Complexes using NMR”

23 February, 2006
Subra Suresh, MIT
“Nanomechanics of Living Cells and Human Disease States”

13 April, 2006
Daniel Chiu, University of Washington
“Single Molecule Methods for Probing Synaptic Function”

4 May, 2006
Ron Weiss, Princeton University                     
“Synthetic Biology: From Bacteria to Stem Cells”

25 May, 2006
Jennifer Cochran, Stanford University
“Engineering Proteins for Therapeutic Applications”

2004/2005 Series:

14 October, 2004
Mark Denny, Stanford University
“Calculating Catastrophes: The Probability and Consequences of Environmental Coincidence”

18 November, 2004
Carolyn Larabell, UCSF
“Cryo X-ray Tomographic Imaging of Cells with Synchrotron Radiation”

2 December, 2004
Frances Arnold, Caltech
“Design by Directed Evolution”

13 January, 2005
Wing Wong, Stanford University
“Transcriptional Profiling and Cis-Regulatory Analysis in Embryonic Stem Cells”

3 February, 2005
Don Engelman, Yale University
Special Seminar, “Folding and Evolution of Membrane Proteins”

10 February, 2005
Christine Schmidt, University of Texas at Austin
“Engineering Strategies for Functional Nerve Repair”

10 March, 2005
Bernhard Palsson, UCSD
“Bringing Genomes to Life: The use of Genome-Scale in silico Models”

7 April, 2005
Paul Thompson, UCLA
“Analyzing Brain Changes in Alzheimer’s Disease, Development, and Schizophrenia”

5 May, 2005
John Spudich, University of Texas
“Rhodopsins: Transducing Light to Biological Energy and Vision in the Microbial World”

19 May, 2005
Rakesh Jain, Harvard University
“Imaging the Inner Workings of Solid Tumors: A 25 Year Odyssey”

2003/2004 Series:

Michael Kahana,  Brandeis University
“From Oscillations to Neuronal Activity - The Neurophysiology of Human Spatial Navigation”

Kristi Anseth, University of Colorado Boulder
“Engineering Gels to Control Cell Function and Tissue Development”

Gene Myers, University of California, Berkeley
“Efficient Algorithms for Comparing Genomes”

Stuart Goodman, Stanford University
“The Foreign Body Reaction to Orthopaedic Implants”

Thomas V. O'Halloran, NorthWestern University
“Posttranslational Regulation of Superoxide Dismutase: Aggregation State control by Metals, Oxygen and the Copper Chaperone, CCS”

Peter Davies, University of Pennsylvania
“The Focal Origin of Atherosclerosis: Integration of genomics into hemodynamic endothelial Mechanotransduction in vivo”

2002/2003 Series:

10 October, 2002
Krishna Shenoy, Stanford University
“Toward Neural Control of Prosthetic Devices”

14 November, 2002
Larry S. B. Goldstein, University of California San Diego /HHMI
“Molecular Motor Proteins in Neuronal Signaling & Disease”

5 December, 2002
Rama Ranganathan, UT Southwestern/HHMI
“Information Flow in Protein Molecules”

16 January, 2003
Erik Winfree, Caltech
“Biomolecular Computing with DNA”

13 February, 2003
Stephen Quake, Caltech
“Sequence, Structure, Function: A Journey in Biophysics from Technology to Science”

13 March, 2003
Joachim Frank, Wadsworth Institute/HHMI
“The Ribosome: Dynamics of Structure and Ligand Interactions as Inferred by Cryo-Electron Microscopy”

17 April, 2003
Ralph Weissleder, Harvard University
“Advances in Molecular Imaging”

8 May, 2003
Anthony Atala
, Harvard University
“Tissue Engineering, Stem Cells and Cloning: Applications for Regenerative Medicine”

22 May, 2003
Larry McIntire, Rice University
“Effect of Mechanical Forces on Gene Expression in Vascular Cells: Implications for Tissue Engineered Arteries”

2001/2002 Series:

11 October, 2001
Ken Salisbury, Stanford University
“Robotic and Virtual Surgery”

15 November, 2001
Irv Weissman, Stanford University
“Biology and Transplantation of Stem and Progenitor Cells”

6 December, 2001
David Agard, University of California, San Francisco
“Tackling Cellular Structure in 3D: Pushing the limits of light and Electron Microscopy”

17 January, 2002
Alexander Van Oudenaarden, MIT
“Challenging Physics Problems in Quantitative Biology: Noise, Self-organization, and Pattern Formation”

21 February, 2002
Paul Rainey, University of Oxford
“The Causes of Ecological Diversity: Insights from Experimental Bacterial Populations”

11 April, 2002
Joanne Chory, Salk Institute for Biological Studies
“Light, Brassinosteroids, and Plant Development”

23 April, 2002
Stephen Harrison, Harvard University
“Putting Together a Virus ... and Taking it Apart”

8 May, 2002
Jill Helms, University of California-San Francisco
“Mechanical Stimuli and Molecular Signals Mediating Skeletal Tissue Regeneration”

30 May, 2002
Charles Turner, Indiana University
“Why Isn’t the Human Skeleton Built to Last?”

2000/2001 Series:

10 January, 2001
Richard Zare, Stanford University
“Some Dreams of Using Mass Spectrometry for Proteomics”

23 February, 2001
Mu-Ming Poo, University of California, Berkeley
“Local and Distributed Synaptic Modifications in Neural Networks induced Patterned Stimulation”

9 March, 2001
David Stuart, University of Oxford, UK
“Piecing Together How dsRNA Viruses Work as Miniature, Self-Assembling, Factories”

6 April, 2001
Adam Arkin, University of California, Berkeley
“Comparative Regulatory Motif Analysis in Cellular Sensing and Switching”

20 April, 2001
David Walt, Tufts University
“Optical Sensor Microarrays: From High Throughput Screening to Artificial Onfaction”

18 May, 2001
Alice Gast, Stanford University
“Ordering in Two-Dimensions - Physical Chemistry Lessons from Proteins”

4 June, 2001
Jeffrey Hubbell, Swiss Federal Institute of Technology and University of Zurich
“Materials-Based Therapeutics:  Blending the Boundaries between the Drug and the Drug Carrier”

1999/2000 Series:

7 October, 1999
Steven Block, Stanford University
“Using Optical Tweezers to Study Biological Motors”

4 November, 1999
Axel Brunger, Yale University
“Towards a Molecular Understanding of Neurotransmission”

9 December, 1999
Stanley Prusiner, University of California - San Francisco
“Dissecting the Etiologies of Degenerative Diseases & Developing Therapeutics through Studies of Prions”

13 January, 2000
W.E. Moerner, Stanford University
“Shedding Light on Single Biomolecules”

10 February, 2000
Stuart Schreiber, Harvard University
“Chemical Genetics”

2 March, 2000
Daniel Branton, Harvard University
“Nanopore Sequencing: Characterizing Single Molecules in Milliseconds”

6 April, 2000
Mimi Koehl, University of California - Berkeley
“Smelling with Hairy Little Noses and Feeding With Hairy Little Legs”

4 May, 2000
Julie Theriot, Stanford University
“Protein Polymerization and Force Generation in Cell Motility”

1 June, 2000
John Doyle, California Institute of Technology
“Robustness, Necessity and Biological Complexity”


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