ALEXANDER DUNN, DEPARTMENT OF CHEMICAL ENGINEERING
Attend Dr. Dunn's pre-seminar presentation to learn more about Dr. Roger Kamm's seminar, "In Vitro Vascularized Models for Metastatic Cancer", to be held Thursday, May 19th.
In this talk, Dr. Kamm will present some recent advances in modeling the successive stages of metastatic cancer, especially in the context of immunotherapies and organ-specific models of metastasis.
OVIJIT CHAUDHURI, DEPARTMENT OF MECHANICAL ENGINEERING
Attend Dr. Chaudhuri's pre-seminar presentation to learn more about Dr. Linda Griffith's seminar, "Move Over, Mice: How Integration of Systems Biology with Organs-on-Chips May Humanize Therapeutic Development", to be held Thursday, April 28th.
“Mice are not little people” – a refrain becoming louder as the strengths and weaknesses of animal models of human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell and intracellular signaling networks in patient-derived samples; 3D tissue engineered models of human organ systems, often made from stem cells; and micro-fluidic and meso-fluidic devices that enable living systems to be sustained, perturbed and analyzed for weeks in culture. This talk will highlight the integration of these rapidly moving fields to understand difficult clinical problems, with an emphasis on translating academic discoveries into practical, widespread use.
BIANXIAO CUI, DEPARTMENT OF CHEMISTRY
Attend Dr. Cui's pre-seminar presentation to learn more about Dr. Chandra Tucker's seminar, "Optical Control of Protein Activity Using Engineered Photoreceptors", to be held Thursday, April 7th.
CHANDRA TUCKER, UNIVERSITY OF COLORADO AT DENVER
Dr. Tucker will discuss recent work using CRY2 to regulate protein-protein interactions, alter protein localization, induce enzyme activity, or disrupt protein function using light.
JOSEPH LIAO, DEPARTMENT OF UROLOGY
Attend Dr. Liao's pre-seminar presentation to learn more about Dr. Jeff Tza-Huei Wang's seminar, "Discerning Rare Disease Biomarkers by Micro- and Nanotechnologies", to be held Thursday, March 10th.
JEFF TZA-HUEI WANG, JOHNS HOPKINS UNIVERSITY
Dr. Wang’s group has developed highly sensitive, quantitative and clinically relevant technologies for analysis of genomic markers based on the convergence of SMS, microfluidic manipulations, and quantum dots.
MICHAEL LIN, DEPARTMENTS OF NEUROBIOLOGY AND BIOENGINEERING
Attend Dr. Lin's pre-seminar presentation to learn more about Dr. David Schaffer's seminar, "Novel Technologies to Investigate the Neural Stem Cell Niche", to be held Thursday, February 11th.
Over the past decade, Dr. Schaffer's group initially developed and has been implementing directed vector evolution as a high throughput approach to engineer adeno-associated virus (AAV) variants with novel properties, including enhanced biodistribution and spread, targeted delivery to specific cells such as stem cells or their neighbors, and gene editing within a cell. This talk will discuss directed evolution of novel and biomedically relevant AAV variants, as well as the application of gene delivery technologies to investigate cells and stem cells in the nervous system.
