Autophagy dynamics in neuronal homeostasis and neurodegeneration
Stanford Bio-X Frontiers in Interdisciplinary Biosciences Seminar
ERIKA HOLZBAUR, UNIVERSITY OF PENNSYLVANIA
Dr. Holzbaur's lab is interested in exploring the dynamics of autophagy and mitophagy in neurons, including compartment biogenesis, cargo recognition and capture, and active transport coupled to cargo degradation. Approaches in the lab include live cell imaging in cell lines and primary neurons, in vitro reconstitution assays with single molecule resolution to analyze dynamics of motors and the cytoskeleton, and the development and analysis of animal models for neurodegenerative disease.
