Home Department: Biology
Supported by: Burroughs Wellcome Fund
Mentor: Judith Frydman, Biology and Genetics

Huntington’s Disease (HD) is one of many neurological disorders caused by the aggregation of misfolded proteins. Specifically, HD results from the aggregation of the pathogenic protein Huntingtin (Htt). Harrison will investigate the mechanisms by which a specific amino acid sequence (N17) on pathogenic Htt contributes to the formation of early-stage Huntingtin oligomers and how these oligomers affect HD’s pathogenesis.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2016:

The Role of N17 in Huntingtin Pathogenesis

Alex Feldman¹, Koning Shen¹, Judith Frydman¹
[Department of Biology¹, Stanford University]