2017 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Bio-X
Mentor: Carla Shatz, Biology and Neurobiology

Photo of USRP student Alan Wei in the laboratory, putting samples into a large piece of lab equipment.Memories are stored at synapses, and if mechanisms driving the loss and extensive pruning of synapses known to occur in Alzheimer’s Disease (AD) were understood, then this devastating disease could be halted or even reversed. The aim of Alan’s project is to study the role of a neuronal receptor, PirB, in synapse pruning during normal developmental critical periods and in the adult mouse cerebral cortex. These experiments should expand our understanding of how PirB receptor works in mice, and may even aid in translating the results to Alzheimer’s disease in human patients.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Developmental Expression of the Non-Classical MHC1 Qa-1, a Regulator of Visual Plasticity

Alan Y. Wei1, Ioana A. Marin1, Kylie S. Chew1, Carla J. Shatz1,2
[Departments of Biology1 and Neurobiology2, Stanford University]