2015 Undergraduate Summer Research Program Participant

Home Department: Biomedical Computation
Supported by: Dean of Research
Mentor: Scott Dixon, Biology

Alex Wells is analyzing the cell death pathway activated by the classic chemotherapeutic agent TMZ. TMZ is effective in only a subset of patients, and resistance to TMZ remains poorly understood. Through the use of a live-cell imaging system, Alex plans to identify the pathways that modify the response of GBM cells to TMZ and develop computational tools to analyze the data generated by this novel imaging system. This research has the potential to reveal new mechanisms of cell death regulation, which could be used to improve the effectiveness of chemotherapeutic drugs.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 26, 2015:

A Web-Based Repository of Drug-Induced Cancer Cell Death Phenotypes

Alex Wells1, Marisa Hom1, Scott Dixon1
[Department of Biology1, Stanford University]