2023 Undergraduate Summer Research Program Participant

Home Department: Chemistry
Mentor: Calvin Kuo (Medicine - Hematology)

“Modeling Wilms Tumor in ALI Kidney Organoids”

Alyssa’s research aims to better understand Wilms Tumor, the most common type of kidney cancer in children, by using innovative air-liquid interface (ALI) kidney organoids as a 3D model. By manipulating the expression of two oncogenes, Alyssa will investigate their role in transforming kidney tissue and promoting tumor development. The organoids will then be examined for changes associated with tumorigenesis using staining methods and gene expression analysis.