Bio-X Graduate Student Fellow

Awarded in 2013
Home Department: Bioengineering
Faculty Advisors: KC Huang (Bioengineering)

Research Title: High-throughput exploration of the phenotypic space in Escherichia coli shape mutants

Research Description: The recent increase in antibiotic resistance in disease-causing bacteria calls for new approaches to drug target selection and drug development. FtsZ, a bacterial cytoskeletal protein critical in cell division, is a powerful target for potential inhibition. Recently crystallized structures of FtsZ bound to a weak inhibitor provide an opportunity for using structure-based computational tools to design new FtsZ inhibitors. By analyzing FtsZ across various bacterial species and across time, we can better understand the molecular basis of Ftsz interaction with inhibitors. We can then develop and apply computational tools for drug repurposing or fragment-based drug design to later pursue with experimental studies.


Amanda is a senior data scientist for the consultant company Hitachi Solutions.