Photo of smiling female undergraduate student Amari Paul.
2021 Undergraduate Summer Research Program Participant

Home Department: undeclared
Mentor: Maria Grazia Roncarolo (Pediatrics - Stem Cell Transplantation and Medicine - Blood & Marrow Transplantation)

“Novel Approaches to Terminate Pediatric Acute Myeloid Leukemia Cells”

The Roncarolo Lab’s research focuses on the antileukemia properties of CD4+ T cells engineered to express human IL-10 gene (LV-10) to bolster progress in killing pediatric acute myeloid leukemia. Amari is investigating the mechanisms underlying the anti-tumor capacity of the LV-10 cells through single-cell RNA sequencing and bioinformatic analyses. The in-depth preclinical studies will give us a better understanding of possible novel approaches to terminate pediatric AML cells in the near future.