Awarded in 2017
Home Departments: Bioengineering, MSTP
Faculty Advisors: Sanjiv Sam Gambhir (Radiology) and Crystal Mackall (Pediatrics - Hematology/Oncology, Medicine)

Research Title: Tumor Selective Antigen Induction for Targeted CAR T-Cell Therapy

Research Description: Chimeric antigen receptor (CAR) T-cell therapy has emerged as a potentially curative immunotherapy for liquid tumors, but limited infiltration and lack of targetable antigens have resulted in severe side-effects and poor efficacy for solid tumors. Amin will introduce a novel combinatorial immunotherapy to improve CAR T-cell efficacy in solid tumors and propose the use of real-time in-vivo imaging to determine the mechanism of tumor clearance and optimize the therapy.  This strategy is a highly innovative advance in rational immunotherapy design and has significant translational potential for solid tumors.

WHERE IS HE NOW?

Amin is a Clinical Fellow in Hematology & Oncology at Dana-Farber Cancer Institute.