Dr. Andrew Gentles's lab is interested in computational systems biology, primarily in cancer. They develop and apply methods to understand biological processes underlying disease, using high-throughput genomic and proteomic datasets and integrating them with phenotypes and clinical outcomes.
Computational biology develops and applies tools to suggest answers to biological questions that can be answered through analysis of large complex datasets. The Gentles lab uses these tools to study humans in both health and disease, by exploiting natural variation across large cohorts of samples. Much of the lab's work is in cancer and neurodegenerative disease, but they have collaborations in various areas.