Home Departments: Biology and Economics
Supported by: Bio-X
Mentor: Irving Weissman, Developmental Biology and Pathology Stem Cell Institute

Prostate cancer metastasizes to the bone with the help of CDCP1, a surface protein shared by hematopoietic stem cells (HSC), which allows cancer cells to colonize the HSC niche. Anoop is investigating the effectiveness of a CDCP1 antibody in preventing the growth and spread of metastatic prostate cancer. He also aims to understand the effect of the antibody on tumor-associated immune cells by applying novel RNA sequencing techniques to treated and untreated models.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Investigating the Role of CDPC1 and CD47 in Metastatic Prostate Cancer Immune Evasion and Tumorigenesis

Anoop Manjunath¹, Gunsagar S. Gulati², Rosalynd Upton², Elly Seo³, Owen Marecic³, Michael Lopez³, Jun Seita⁴, Debashis Sahoo⁵, Anne Leyrat⁶, Michael Gonzales⁶, Norma Neff⁷, Sopheak Sim⁴, Stephen Quake⁷, Michael T. Longaker³, Charles K. F. Chan³, Irving L. Weissman^8,9
[Departments of Biology¹, Cancer Biology², Surgery³, Bioengineering⁷, Pathology⁸, and Developmental Biology⁹ and Institute for Stem Cell Biology & Regenerative Medicine⁴, Stanford University; Department of Pediatrics⁵, University of California, San Diego; Fluidigm Corporation⁶]