2017 Undergraduate Summer Research Program Participant

Home Departments: Biology and Economics
Supported by: Bio-X
Mentor: Irving Weissman, Developmental Biology and Pathology Stem Cell Institute

Prostate cancer metastasizes to the bone with the help of CDCP1, a surface protein shared by hematopoietic stem cells (HSC), which allows cancer cells to colonize the HSC niche. Anoop is investigating the effectiveness of a CDCP1 antibody in preventing the growth and spread of metastatic prostate cancer. He also aims to understand the effect of the antibody on tumor-associated immune cells by applying novel RNA sequencing techniques to treated and untreated models.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Investigating the Role of CDPC1 and CD47 in Metastatic Prostate Cancer Immune Evasion and Tumorigenesis

Anoop Manjunath1, Gunsagar S. Gulati2, Rosalynd Upton2, Elly Seo3, Owen Marecic3, Michael Lopez3, Jun Seita4, Debashis Sahoo5, Anne Leyrat6, Michael Gonzales6, Norma Neff7, Sopheak Sim4, Stephen Quake7, Michael T. Longaker3, Charles K. F. Chan3, Irving L. Weissman8,9
[Departments of Biology1, Cancer Biology2, Surgery3, Bioengineering7, Pathology8, and Developmental Biology9 and Institute for Stem Cell Biology & Regenerative Medicine4, Stanford University; Department of Pediatrics5, University of California, San Diego; Fluidigm Corporation6]