Home Department: Chemistry
Mentor: Thomas Südhof (Molecular & Cellular Physiology and Neurosurgery)

“Understanding the Roles of ApoE2 and ApoE4 in Alzheimer’s Disease Pathology”

Aubrey’s project aims to investigate the role of human apolipoprotein E (ApoE) isoforms, particularly ApoE2 and ApoE4, in Alzheimer’s disease pathology, focusing on their interaction with amyloid-β (Aβ) in the brain. This will be achieved through robust experimental approaches, including the differentiation of human embryonic stem cells into neurons and co-culturing with ApoE-producing glial cells. Key experiments will monitor Aβ levels, evaluate the impact of pharmacologically eliminating Aβ, and assess synapse number and activity. These methodologies will provide comprehensive insights into the ApoE-Aβ interaction, potentially unveiling new therapeutic targets for Alzheimer’s disease.