Home Department: undeclared
Mentor: Merritt Maduke (Molecular & Cellular Physiology)

“Molecular Recognition of a Novel Inhibitor by Voltage-Gated Chloride Channels in the Brain”

The CLC-2 ion channel facilitates selective passage of Cl– ions across cell membranes. In the central nervous system, CLC-2 is expressed in both neurons and glia and is proposed to regulate electrical excitability and ion homeostasis. CLC-2 has been implicated in various central nervous system disorders. Working in the Maduke lab, Audrey aims to determine the molecular basis for how the inhibitor “AK-42” interacts with and inhibits CLC-2.