Home Department: undeclared
Mentor: William Goodyer (Pediatrics)

“Deconvolution of the Proteomic and Transcriptomic Landscape of the Human Cardiac Conduction System”

Coordinated beating of the heart requires a specialized group of cells known as the cardiac conduction system (CCS), essentially the electrical wiring of the heart. The CCS is critical for the heart’s normal function and development, however, much remains unknown of the molecular regulators that govern the CCS. Bowen’s research project will employ both single-nucleus RNA sequencing and, in collaboration with the Lundby lab in Denmark, proteomics of previously isolated human conduction tissue to provide a first-in-kind, comprehensive gene and protein expression atlas for facilitating future efforts in conduction cell identification and characterization in the context of development and disease.