2017 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Vice Provost for Undergraduate Education
Mentor: Kathleen Sakamoto, Pediatrics

The Ribosomal S6 Kinase (RSK) has been linked to the proliferation of acute myeloid leukemia, and efforts at targeting RSK have had differential effects on normal and leukemic cells. Bruce will work to characterize the role of RSK in the myeloid development of normal hematopoietic cells. This project seeks to better profile important players in myelopoiesis and study signaling pathways downstream of RSK that may be appropriate for future therapeutics.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Inhibition of the Ribosomal S6 Kinase Causes Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia Cells

Bruce Tiu1, Hee-Don Chae1, Ritika Dutta1, Kathleen Sakamoto1
[Department of Pediatrics1, Stanford University]