The laboratory mouse is the most widely used mammalian model for biomedical research and comprises over 90% of the non-aquatic, laboratory animals at Stanford.  As Director of the Rodent Health Surveillance Program and the Director of Rodent Services, Dr. Nagamine's research and clinical expertise is in mouse reproductive biology, mouse models of mammalian sex determination and sexual differentiation, and mouse models of infectious diseases.  Past research focused on the molecular genetics underpinning a mouse model of XY sex reversal and the effect of the bacterial pathogen Helicobacter hepaticus on chemical and genetic models of colon cancer.  Current collaborative research is the development of a mouse model for dengue virus to study the relationship between autophagy and dengue virus virulence.