Bio-X Affiliated Faculty

As a statistician interested in probability theory, Dr. Siegmund focuses his research on statistical problems that arise in concrete scientific applications and require novel probability theory for their resolution. Until 1985 his research was primarily in sequential analysis, especially problems of the design and analysis of sequential clinical trials. A related interest was sequential change-point detection, motivated by problems of monitoring a continuous production process for changes that can be inferred only from noisy measurements on its output. This led to several years of research on a variety of change-point-like problems and related problems of nonlinear regression, which have found a wide variety of applications.

Recently he has concentrated on statistical aspects of genetic mapping, i.e., the identification of the location of genes giving rise to phenotypes such as diseases in humans or mammalian model organisms, desirable quantitative traits in agriculturally important plants and domestic livestock. From the modern viewpoint of a "genome scan" based on hundreds of mapped markers to search for anonymous genes, genetic mapping is very similar to change-point problems with the location of the gene as change-point. He has also used techniques developed to study change-point problems to give approximate p-values for gapped pairwise local sequence alignments.