Dr. Rosen's laboratory examines apoptotic and cell signaling pathways in the lung with a focus on fibrotic lung disease and lung cancer. They are studying TGF beta signaling in lung cells which regulates fibroblast and epithelial activation. They are also studying non-canonical functions of TERC and Tert in regulation of transcription in cancer cells and activated lung epithelium. The analysis of TERC lncRNA regulation of transcription ,which is done in collaboration with Dr. Howard Chang. They also are involved in trials of novel therapeutics for patients with pulmonary fibrosis.