2022 Undergraduate Summer Research Program Participant

Home Department: Undeclared
Mentor: Anthony Oro (Dermatology)

“Optimizing Electrospray on Skin Technology for Cell Therapy Delivery”

The Oro lab has developed a scalable genetically corrected cell therapy platform for Recessive Dystrophic Epidermolysis Bullosa (RDEB) patients called DEBCT. The platform, however, requires optimization of tissue stem cell delivery using a novel electrospray-on-skin device. Grace’s project will correlate DEBCT cell product composition with electrosprayer performance to heal murine skin wounds over two weeks. The Oro lab will use varying human cell compositions of immune pluripotent stem cell (iPS)-derived keratinocytes, fibroblasts and endothelial cells, and measure their wound healing capabilities using a variety of tissue measurement markers. This study will provide the basis for potential future clinical trial studies with DEBCT and the electrosprayer to address RDEB wound healing efficacy.