2017 Undergraduate Summer Research Program Participant

Home Department: undeclared
Supported by: Bio-X
Mentor: Helen Blau, Microbiology & Immunology

Photo of USRP student Helen Liu in the lab, putting samples into a machine.Many of the receptors that regulate cell fate and self-renewal are G-protein coupled receptors (GPCRs). Discovering drugs for muscle repair is challenging because it has been difficult to discover drugs for cell fate regulating GPCRs. To overcome this issue, Helen will develop an innovative new system to create a library of single variable chain antibodies (nanobodies) that will be able to target GPCR as agonists to the receptors and may also lead to other novel treatments.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

Discovering Agonist Nanobodies to Muscle Stem Cell GPCRS for Use as Therapeutic Biologics

Helen Liu1,2,3, David M. Burns1,2,3, Helen Blau1,2,3
[Baxter Laboratory for Stem Cell Biology1, Department of Microbiology & Immunology2, and Institute for Stem Cell Biology & Regenerative Medicine3, Stanford University]