Dr. Hunter Fraser's laboratory study the regulation and evolution of gene expression using a combination of experimental and computational approaches.
Their work brings together quantitative genetics, genomics, epigenetics, and evolutionary biology to achieve a deeper understanding of how genetic variation within and between species affects genome-wide gene expression and ultimately shapes the phenotypic diversity of life.
Some of the Fraser lab's long-term goals are to better understand:
- How new mutations affect gene expression
- What selective pressures act on these mutations
- How (and how often) changes in gene expression affect other phenotypes, including human disease