2010 Undergraduate Summer Research Program Participant

Home Department: Biology
Supported by: Pitch Johnson
Mentor: Alan C. Pao, Assistant Professor of Medicine (Nephrology)

Huy Phan, a junior at Stanford, is majoring in Biology with plans to attend medical school. He has been working with the Pao Lab to characterize the water-excreting properties of the newly-discovered compound OADS. In vitro studies have shown that OADS inhibits the CLC-Ka channel in the thin ascending limb of the kidney; its blockage may lead to a water diuresis. In order to accurately characterize OADS, Huy has been doing in vivo studies to collect data on the effect of OADS on rats. Working in the lab this summer has allowed Huy to explore the world of medical research.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 25, 2010:

The Diuretic Effect of a Small Molecule Inhibitor of CLC-K1 in Rats

Huy D. Phan1, Paru P. Kathpalia, MD1, Andrew E. Howery2, Justin Du bois2, Lise Bankir, PhD3, Merritt Maduke, PhD1, and Alan C. Pao, MD1
[Stanford University School of Medicine, Palo Alto, CA, United States1; Department of Chemistry, Stanford University, Palo Alto, CA, United States23]