Home Department: Biology and Music
Mentor: Helen Blau (Microbiology & Immunology)

“15-PGDH Inhibition as an Antifibrotic for Dilated Cardiomyopathy”

Ireh’s project focuses on finding a potential treatment for dilated cardiomyopathy (DCM), a cardiovascular disease characterized by heart enlargement and fibrosis. The Blau lab aims to investigate the effects of inhibiting the enzyme 15-PGDH using a small molecule called SW033391 (SW) on cardiac fibrosis and heart function. The hypothesis is that inhibiting 15-PGDH will reduce fibrosis and improve heart function in mice with DCM. Ireh’s project explores a potential therapy for DCM and hopes to gain a deeper understanding of the underlying mechanisms involved in cardiac fibrosis.