Home Department: undeclared
Mentor: Melody Smith (Medicine - Blood & Marrow Transplantation)

“Off-the-shelf Fully Human CD5/CD7 Bispecific VH CAR-γδ T cell Therapy to Treat T cell Malignancies”

T cell malignancies are a serious and life-threatening disease characterized by the abnormal growth of T cells. Current treatments for relapses are ineffective.
Isabella aims to develop a therapy that is ready-to-use and utilizes special cells called γδ T cells from healthy donors. These cells are equipped with special tools, known as Chimeric Antigen Receptors (CARs), which are designed to target two markers on the cancer cells and offer a potentially novel way to kill T-cell malignancies.