2017 Undergraduate Summer Research Program Participant

Home Department: Bioengineering
Supported by: Anonymous Donor
Mentor: Sean Wu, Medicine (Cardiovascular)

Clinical attempts at myocardial tissue grafting have shown limited success due to the insufficient vascularization and poor control on the scaffold structure. James is utilizing the 3D bioprinting of IPSC-derived cardiomyocytes, endothelial cells, and biomaterials to create and test various vascular network designs in order to address these challenges. The proposed research could establish design principles that lead to the creation of the first 3D bioprinted, patient-specific, vascular myocardium, which can be broadly applicable to other tissues and organs.

Poster presented at the Stanford Bio-X Interdisciplinary Initiatives Symposium on August 24, 2017:

3D Bioprinting of Vascular hiPSC-Based Cardiac Tissue

James B. Hu1, Ken T. Hinh1, Daniel A. Hu1, Ryan Ferdowsian1, Sneha Venkatraman1, Orlando Chirikian1, Jan W. Buikema1, Vahid Serpooshan1, Sean Wu1,2,3
[Stanford Cardiovascular Institute1, Institute for Stem Cell Biology & Regenerative Medicine2, and Department of Medicine (Division of Cardiovascular Medicine3), Stanford University]