Home Department: Biology
Mentor: Michelle Monje, Neurology & Neurological Sciences

“Examining Pediatric High-Grade Glioma with scRNA-seq”

In pediatric high-grade glioma, interactions between neurons and malignant cells are highly relevant to tumor progression. Dissecting glioma cells’ varied niches and microenvironmental interactions with neurons could therefore provide insight into this extremely deadly and aggressive cancer. James’s project will use single-cell RNA sequence analysis to investigate glioma cell subpopulations and their potential roles in synapse formation and tumor progression.