Photo of smiling female undergraduate student Jenny Shi.
2021 Undergraduate Summer Research Program Participant

Home Department: undeclared
Mentor: Karl Deisseroth (Bioengineering and Psychiatry & Behavioral Sciences)

“Single-Cell 3D Chromatin and Spatial Transcriptomic Characterization of the Cerebellum During Normal Development and Autism”

Studying the single-cell 3D genome and spatial transcriptome of the brain can elucidate relationships between DNA structure, gene expression, and brain circuitry in mental disorders and enable effective treatments. However, this is difficult with existing technology. To better understand the molecular differences between brains with and without autism, Jenny is integrating single-cell data from Dip-C (visualizes how chromosomes are organized in a cell) and STARmap (maps and sequences single RNA molecules in the brain). She is developing algorithms to characterize how the 3D genome and transcriptome change and interact during the development of mouse and human cerebellums.